Institute for Medical BioMathematics, Bene Atarot, Israel


Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Poland


Israel-Poland workshop

20 – 24, February 2020


From equations to the patient’s bedside: role of biomathematics in solving medical problems in real-life

Most of the known pathological processes take place across different levels of organization of the biological system, from the genetic, cellular, tissue and organ levels, through those of whole organisms and populations. The new technologies in molecular biosciences provide accessibility to extensive molecular and cellular data of these processes. The big challenge is now to explain how these data are translated into the ‘‘events’’ which may be clinically observed. Mathematical modeling can be an essential player in this domain, by reasoning biological processes, considering their spatio-temporal and multi-scale character. Multi-scale modeling already has contributed to the development of the “virtual patient’’ concept, which begins to have a genuine impact in optimizing and adjusting treatments to individual patient needs.

The workshop is devoted to mathematical modeling and analysis of disease processes, with a special focus on tumor growth and therapy. It will include lectures on diverse related subjects, such as gene expression, drug resistance, epidemiology, and molecular aspects of the healing process. Recent mathematical methodologies, results and theoretical analyses of the nonlinear disease dynamics will be discussed. We hope that during this workshop new perspectives and future cooperation between Israeli and Polish researchers will be formed, and expect the participants to benefit from sharing their ideas and initiating new liaisons.





“Modelling Complex Biological Systems in the Context of Genomics” May 21- 25, 2012, Évry, France

The challenge of the post-genomic era is to create a new integrated picture of the cell which takes into account that it is simultaneously an autocatalytic set, a tensegrity structure, a network or a set of networks with particular connectivity and feedback characteristics, a set of codes and decoding devices, a self-organising system etc. Taking on this challenge therefore also requires the introduction of concepts unfamiliar to biologists and the development of new ones, the formulation of new hypotheses and their testing via simulations or wet experiments.

Taking on this challenge therefore requires specialists from across the sciences to learn each other’s language so as to collaborate effectively on defined projects. The Thematic School “Modelling Complex Biological Systems in the Context of Genomics” has been set up to help this research effort. The Thematic School was based on five main interest axes: (i) Molecular networks & modelling; (ii) Discrete approaches to regulatory networks; (iii) Genome-scale metabolism; (iv) Cell biophysics; (v) mathematical oncology. It was within the latter axe that Professor Agur was invited as an international expert. She lectured on the development of the Virtual Cancer Patient: from theory to the clinic.

“Mathematical Oncology: New Challenges For Systems Biomedicine 26 – 30 september 2011 Erice (Italy)”

Prof. Zvia Agur from the Institute for Medical BioMathematics (IMBM) has organized Erice school together with Dr. A. d’Onofrio and Prof. A. Gandolfi and gave a lecture titled “Mathematical Models Reveal a Mechanism of Fate Decision in Cancer Stem Cells and suggest Effective Oncotherapy Modalities”

“Biomathematical Modeling and Cancer Immunotherapy Workshop, Bol, Island of Brač, Croatia, June 20-­21, 2011”

Prof Z. Agur from the Institute for Medical BioMathematics (IMBM), together with Prof. Stanimir-Vuk Pavlovic of Mayo Clinic, Rochester, USA, has organized a workshop where bio-mathematicians, physicians and biomedical scientists discussed the role of mathematical models as practical tools for optimizing cancer immunotherapy. The workshop was held during the Seventh ISABS (International Society for Applied Biological Sciences, Zagreb) Conference on Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures of Translational Medicine.

Mathematical Modelling of Cancer Growth and Treatment Summer School & Workshop, West Park Centre, Dundee, August 15th – 28th, 2010

Organized by the Mathematical Biology Group at Dundee University Prof. Agur has accepted an invitation to lecturer in this Workshop on the following subjects:

  • “Mathematically modelling Prostate Cancer immunotherapy and validating the model in clinical trials”
  • “Personalized medicine by the use of mathematical models: validation in a Mesenchymal Chondrosarcoma patient”
  • “Cytokine cancer therapy: a model and its preclinical validation”

Workshop on “Theoretical Insights into Therapeutics for Cancer Stem Cells”, Kibbutz Dalia, Israel, September 9-11, 2008.

The Institute for Medical BioMathematics (IMBM) has organized a workshop on Cancer Stem Cells.
List of Abstracts is available.

Workshop “New Prospects for Cancer Immunotherapy:
Integrating Biomarkers in Mathematical Models”
In the framework of: Marie Curie Research Training Network 

Kibbutz Dalia, May 4-6, 2008
Grant No. MRTN-CT-2004 – 503661

The Institute for Medical BioMathematics (IMBM) has organized a workshop on the integration of biomarkers in Mathematical models for improving the prospects of cellular, cytokine and monoclonal antibody therapy in oncology.
List of Abstracts is available.