After completing his B.Sc. in Life Science and Mathematics at the Hebrew University of Jerusalem, Yuri spent two more years at the Hebrew University studying Near Field microscope applications to micro-manipulations in biophysics under the supervision of Prof Aharon Lewis (see 1). Yuri holds an M.Sc. degree in Applied Mathematics from the Technion, Israel Institute of Technology. His M.Sc. study involved mathematical combustion theory. At IMBM Yuri employs his skills in applied mathematics for developing mechanism-based models of cancer drug therapy and its accompanying physiological side effects.
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Scientific activity in 2009
A general mathematical model of thrombocyte dynamics under chemotherapy combined with IL-11 treatment has been formulated. It has been calibrated on PK/PD data on thrombocyte dynamics under chemotherapy and under IL-11 treatments. The conditions for an existing single stable steady state have been found. Optimal treatment regimens with IL-11 of patients treated with carboplatin during one month have been found. It has been proved statistically that the differences in regimens are significant. The obtained results are incorporating now into the paper.
Work program for 2010
This year, Yuri's research subjects will be as follows:
Finding an optimal treatment regimen with IL-11 for topotecan treated patients. Comparison of the results to those of carboplatin treated patients.
Extension of these estimation results to two cycles of chemotherapy administered over the course of 3 months.
Modeling cancer immunotherapy with IL-12.
Publications
- Lewis A, Kheifetz Y, Shambrodt E, Radko A, Khachatryan (1999). A. Fountain pen nanochemistry: Atomic force control of chrome etching. Applied physics letters, vol. 75, no. 17: 2689-2691.
- Kheifetz Y, Kogan Y, Agur Z. (2004). Matrix and compact operator description of resonance and antiresonance in cell populations subjected to phase specific drugs, Journal of Medical Informatics & Technologies, October Vol. 8: MM-11 – MM-29.
- Forys U, Kheifetz Y, Kogan Y. (2005). Critical point analysis for three-dimensional cancer angiogenesis models, Mathematical Biosciences and Engineering. August vol.2, Number
- Kheifetz Y, Kogan Y, Agur Z. (2006). Long-range predictability in models of cell populations subjected to phase-specific drugs: growth-rate approximation using properties of positive compact operators, Mathematical Models and Methods in Applied Sciences(M3AS) - Vol. 16, No. 8.
- Kheifetz Y, Elishmereni M, Horowitz S, Agur Z. (2006). Fluid-retention side-effects of the chemotherapy-supportive treatment Interleukin-11: Mathematical modelling of putative underlying mechanisms. Computational and Mathematical Methods in Medicine., 7(2-3):71-84.
- Elishmereni M, Kheifetz Y, Agur Z. New strategies of Interleukin-11 therapy for thrombocytopenia based on a mathematical PK/PD analysis. (In preparation).
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