Yuri Kogan

Yuri is studying for MA degree in mathematics, in the Einstein Institute of Mathematics in the Hebrew University, in Jerusalem. His current focus of research at IMBM is at modeling cancer growth and treatment, in particular immunotherapy of glioblastomas, and modelling of cancer stem cells, as a part of NEST project .

Scientific activity in 2007

  • Coordinating IMBM project within Cancer Stem Cells NEST project (with prof. Zvia Agur).
  • Development and analysis of generic model for cancer stem cell dynamics (with Oleg Kirnasovsky and Vladimir Vainshtein), validation of the model by tumour growth experiments.
  • Mathematical analysis and simulations of a model for malignant gliomas (grade III and grade IV brain tumor) using alloreactive CTL infusions (with Natalie Kronik and Urszula Forys).

Work program for 2008

  • Coordinating IMBM participation in Cancer Stem Cells NEST project (with prof. Zvia Agur).
  • Mathematical analysis of a new model for glioblastoma and its treatment by immonutherapy (with Natalie Kronik, Ofir Shukron and Urszula Forys).
  • Validation of the mathematical model developed for immunotherapy for glioblastoma multiforme. We plan a collaboration with an experimentalist groups from the University of Florida, USA, and from other labs (Germany) to test our model and its predictions in mice (with Natalie Kronik).
  • Analysis and integration of neuronal cancer SC models (with Ofir Shukron, Natalie Kronik) – NEST framework.

Lectures/Conferences in 2007

  • Kronik N, Kogan Y, Agur Z. 2006. "Mathematical model validates experimental results for immunotherapyof high-grade brain tumors" A poster presented at the Euroconference "Which mathematics for Biology?", 10-14 July 2006,Anogia, Greece.
  • Banach Center / CIME Courses "From a Microscopic to a Macroscopic Description of Complex Systems" and workshop "Modelling Cellular Systems with Applications to Tumour Growth" (MicroMacro06), Bedlewo, Poland, 4-9 September 2006.
  • Kronik N, Kogan Y, Vainstein V, Agur Z. "Immunotherapy for high-grade brain tumors: validation of experimental results by a mathematical model", a poster presented at the 18th EORTC-NCI-AACR Symposium on "Molecular Targets and Cancer Therapeutics" 7 - 10 November, 2006, Prague, Czeck Republic.
  • "Mathematical analysis of glioblastoma model: first results", given at the Centre for Mathematical Biology, Oxford University, 7 December, 2006, Oxford, UK.
  • “Discussion and planning of experiments for validation of mathematical models”, lecture at EU NEST project “Control Cancer Stem” Consortium Meeting. Manchester, 9 December, 2006
  • “Mathematical model of GBM immunotherapy”, lecture given at Warsaw University, Warsaw, Poland, 16 May 2007.
  • ILSI-Biomed Israel 2007 Conference, Tel-Aviv, Israel, June 5-7, 2007
  • “NEST validation experiments: past, present and future”, lecture at EU NEST project “Control Cancer Stem” Consortium Meeting. Manchester, 2 February, 2008

Publications

  1. Forys U, Kheiffez Y, Kogan Y, Critical point analysis for three-dimensional cancer angiogenesis models,, Mathematical Biosciences and Engineering, vol.2 num.3, August 2005, pp. 511 –525
  2. Kheiffez Y, Kogan Y, Agur Z., 2004. Matrix and compact operator description of resonance and anti-resonance in cell populations subjected to phase-specific drugs. Journal of medical informatics and tecnologies. Vol. 8, 2004, MM11-MM29
  3. Kheifetz Y, Kogan Y, Agur Z, Long-range predictability in models of cell populations subjected to phase-specific drugs: growth-rate approximation using properties of positive compact operators, M3AS, 16(7) Supp, July 2006-11-15.
  4. Arakelyan L, Merbl Y, Daugulis P, Ginosar Y, Vainstain V, Kogan Y, Sleitser V, Harpak H and Agur Z. Using multi-scale mathematical modeling in anti-angiogenic therapy, Chap. 7 in "Cancer Modeling and Simulation" Mathematical Biology and Medicine Series, Chapman & Hall/CRC, June 2003, pp 185-219.
  5. Zvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheiffetz, Irit Ziv, Meir Shoham, and Vladimir Vainstein. Mathematical modeling as a new approach for improving the efficacy/toxicity profile of drugs: the thrombocytopenia case study In Preclinical Development Handbook, Shayne Gad Ed., John Wiley and Sons, USA. 2008, pp 1229-1266.
  6. Kronik N, Kogan Y, Vainstein V, Agur Z, Improving alloreactive CTL immunotherapy for malignant gliomas by a computerized model. Cancer Immunology, Immunotherapy, to appear. Cancer Immunol Immunother. 2008 Mar;57(3):425-439.
  7. Ribba B, Dahan N, Vainstein V, Kogan Y, Marron K, Agur Z. 2004. Doxorubicin efficacy in residual non-Hodgkin’s limphoma disease: towards a computationally supported treatment improvement. MMNP . To appear.
  8. Kirnasovsky O, Kogan Y, Agur Z. Analysis of a Mathematical Model for the Molecular Mechanism of Fate Decision in Mammary Stem Cells, MMNP. To appear.

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