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Dr. Oleg U. Kirnasovsky

Oleg holds a Ph.D. degree in algebra and number theory from the Kiev Taras Shevchenko National University (Ukraine). Dr. Kirnasovsky also studied Mathematics in the Mechanics and mathematics faculty at the Moscow Lomonosov University and teaching of mathematics and informatics in the Physics and mathematics faculty at the Vinnitsa Pedagogical University. His Ph.D. dissertation work involved binary and multiplace group isotopes. In IMBM Dr. Kirnasovsky is involved in the Marie Curie research project MRTN-CT-204-503661 "Using mathematical and computer simulation to improve cancer therapy" and the NEST research project “Developing a virtual and molecular control board for diverting cancer stem cell to non-malignance”

Scientific Activity in 2007

During this year Dr. Kirnasovsky worked on research of two new models of tumour growth within the frameworks of the European Union NEST project “Developing a virtual and molecular control board for diverting cancer stem cell to non-malignance”. One model studies method of distrupting cancer stem cell proliferation by describing stem cells as functional units and cellular level (with Yuri Kogan, Dr. Vladimir Vainstein and Prof. Zvia Agur), while the other mathematically describes the intracellular pathways by which cancer stem cell homeostasis can be disrupted (with Genady Vasserman, Dr. Elina Aizenshtein, Dr. Lilach Tencer and Prof. Zvia Fgur). The second model also was applied to an analysis of the behaviour of a single cell, having a constant microenvironment (with Yuri Kogan and Zvia Agur).

Work program for 2008

During the coming year, Oleg will be engaged in constructing and analyzing new models of cancer stem cells and methods for their elimination. He will be involved in projects, aimed at developing a virtual and molecular control board for diverting cancer stem cell to non-malignance (with Dr. Lilach Tencer and Prof. Zvia Agur), at research of tissue engineering (with Dr. Lilach Tencer and Prof Zvia Agur) at and at research of the effect of cancer of monoclonal antibody drugs (with Dr. Vladimir Vainstein, Dr. Eva Jager and Yuri Kogan under supervision of Zvia Agur).

Publications

Kirnasovsky O.U., Kogan Y, Agur Z. Resilience in Stem Cell renewal: Development of the Agur – Daniel – Ginossar Model. Disc. Cont. Dyn. Systems, Disc.Cont. Dyn. Systems, (in press).
Kirnasovsky O.U., Vainstein V., Kogan Y., Agur Z. System and Method of Evaluation of Stochastic Interactions of a Soluble Ligand with a Target Cell Population for Optimization of Drug Design and Delivery (pending patent application filed and published; Publication Number: WO/2007/034331; International Application No.: PCT/IB2006/003367; Publication Date: 29.03.2007; International Filing Date: 09.06.2006).
Agur Z., Kirnasovsky O.U., Levi L. Normal and Pathological Renewal of Damaged Tissues by Stem Cell Homing Analyzed in a Simple Discrete Model (submitted).
Kirnasovsky O.U., Kogan Y., Agur Z. Analysis of a Mathematical Model for the Molecular Mechanism of Fate Decision in Mammary Stem Cells. MMNP (In press).
Kirnasovsky O.U., Levi L., Agur Z. Modelling Properties of Self-renewable tissues for Tissue Engineering, European Conference on Mathematical and Theoretical Biology, Abstracts, Dresden, Germany, July 18 – 22, 2005, Abstract Booklet 1, P.393.
Kirnasovsky O.U. On Some Subclass of the Class of Regular Agur – Daniel – Ginosar Models of a Bone Marrow Homeostasis, European Conference on Mathematical and Theoretical Biology, Abstracts, Dresden, Germany, July 18 – 22, 2005, Abstract Booklet 2, P.49.