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Ofir Shukron

Ofir holds a B.Sc. degree from Holon Institute for Technology (H.I.T), Department of Applied Mathematics. He majored in Biomathematics and in Signal Processing. Ofir currently pursues a M.Sc. degree in Applied Mathematics at the University of Tel-Aviv, focusing his thesis on image processing. At IMBM Ofir is involved in researching the transformation of myelodysplastic syndrome (MDS) to acute myeloid leukemia (AML). He is also involved in devising medical imaging algorithms.

Scientific activity in 2009

During 2009 Ofir was involved in the following research:

Statistical survival data analysis of MDS patients and the deterioration of MDS to secondary AML, employing the "one hit transformation" model to determine optimal clinical intervention timing for MDS patients (with Dr. Vladimir Vainstein and Zvia Agur).

Improving immunotherapy of alloreactive T lymphocytes for brain tumors (glioblastoma) by analyzing mathematical models of the complex tumor-immune system interactions with mediated proteins. The research aims at improving suggested treatment regimens as well as allowing better understanding of the complex dynamics of the system (with Natalie Kronik , Yuri Kogan, Zvia Agur and Urszula Forys of Warsaw University, Poland)..

Optimizing the delivery of nano-medicine to solid tumors by exploiting the mechanism of Enhanced Permeability and Retention (EPR). Constructing a platform to best fit nano-medicine carrier physiochemical properties to the characteristics of the defective blood vessel at the tumor site. The research aims to allow better accumulation and effective functionality of drugs in the tumor site (with Dr. Karin Halevi and Zvia Agur).

Image analysis of cell populations. Construction of a computerized algorithm for analyzing cancerous cell populations, tracking regions of interest within the batch, and extracting quantitative and qualitative data such as cell recognition, distribution of cells, batch size, recognition and tracking of frequent replicating regions (with Yuri Kogan and Andreas.Lankenau at IBMT, fraunhofer Inst., Germany.

Work Program for 2010

Investigation of the transformation of MDS to AML based on survival data.

Further development of medical image algorithms.