Dr. Lilach Tencer-Herschkovitz

Lilach has completed her Ph.D. studies at the Weizmann institute of science under the supervision of Prof. Moti Liscovitch in the department of biological regulation. Her thesis work has focused on experimentally studying the molecular mechanisms of caveolin-1 induction by PPAR? ligands in human cancer cells. She holds B.Sc. and M.Sc. degrees from Tel-Aviv University, Faculty of Life Science. Her M.Sc. work in the department of Biochemistry focused on how immunoglobulin light chains dictate vesicular transport-dependent and independent routes for IgM degradation by the ubiquitin-proteasome pathway.

Scientific activity in 2009

  • Lilach participated in the cancer stem cell project (NEST), studying the theoretical effects of various signal transduction pathways on stem cell proliferation. She has cooperated with the other participants of the NEST project and has contributed to analysis of the breast cancer stem cell model and its validation by experimental data from the lab (work carried out together with Oleg Kirnasovsky, Zvia Agur and Dr. Robert Clark’s group at the University of Manchester, UK).

    • Publications

    1. Elkabetz, Y., Kerem, A., Tencer, L., Winitz, D., Kopito, R.R. & Bar-Nun, S. (2003). Immunoglobulin light chains are dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway. J. Biol. Chem. 278, 18922–18929.
    2. Burgermeister, E., Tencer, L. & Liscovitch, M. (2003). Peroxisome proliferator-activated receptor-? upregulates Caveolin-1 and Caveolin-2 expression in human carcinoma cells. Oncogene 22, 3888–3900.
    3. Liscovitch, M., Burgermeister, E., Jain, N., Ravid, D., Shatz M. & Tencer, L. (2005). Caveolin and cancer: A complex relationship. In Membrane microdomain signaling: Lipid rafts in biology and medicine. M.P. Mattson, ed. 161–190 (Totowa, New Jersey: Humana press) .
    4. Chen, G., Tencer, L., Ravid, D., Sarfstein, R., Liscovitch, M. & Werner, H. (2006). Caveolin-1 upregulates IGF-I receptor gene trascription in breast cancer cells via Sp-1- and p53-dependent pathways. Experimental Cell Research 312, 3899–3908.
    5. Sarig, R., Fuchs, O., Tencer, L., Panski, A., Nudel, U. & Yaffe, D. (2007). Cloned myogenic cells can transdifferentiate in vivo into neurogenic cells. Submitted.
    6. Tencer, L., Burgermeister, E. & Liscovitch, M. (2008). Rosiglitazone induces caveolin-1 by PPAR? dependent and PPRE-independent mechanisms: Role of EGF receptor signaling and effect on cancer cell drug resistance. Anticancer Research 28, 895–906.

Abstracts

  • Tencer, L., Burgermeister, E. & Liscovitch, M. (2006). A role for EGF receptor and MAP kinase signaling in the induction of caveolin-1 by the PPAR ? ligand rosiglitazone. Proceedings of ISREC 2006 (Lausanne), October 11-13.
  • Burgermeister, E. & Liscovitch, M. (2006). A role for EGFR, MEK1-ERK1/2 and p38 kinases in the induction of caveolin-1 by the PPAR ? ligand rosiglitazone and EGF. Proceedings of the 2nd joint American-Israeli conference on cancer (Jerusalem), 90.
  • Kirnasovsky, O.U., Tencer, L., Vasserman, G. & Agur, Z. (2008). Dickkopf (Dkk) protein as a candidate for diverting proliferating cancer stem cells to terminal differentiation: Evaluation by a mathematical model. American Association for Cancer Research, AACR. Mar 16-19, Dead Sea, Jordan, 28.

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