Dr. Lilach Tencer-Herschkovitz

Lilach has completed her Ph.D studies at the Weizmann institute of science under the supervision of Prof. Moti Liscovitch in the department of biological regulation. Her thesis work has focused on experimentally studying the molecular mechanisms of caveolin-1 induction by PPAR? ligands in human cancer cells. Lilach has completed her B.Sc. and M.Sc. degrees in Tel-Aviv University in the faculty of Life Science. Her M.Sc. work in the department of Biochemistry in Tel Aviv University focused on experimentally studying Immunoglobulin light chains dictate vesicular transport-dependent and independent routes for IgM degradation by the ubiquitin-proteasome pathway. In IMBM, Lilach participates in the cancer stem cell project, theoretically studying the effects of various signal transduction pathways on stem cell proliferation.

Work Program for 2008

  • Lilach's research in 2008 is focused on elucidating the molecular mechanisms governing breast cancer stem cell fate. We aim at diverting cancer stem cells to a more differentiated phenotype a key feature in arresting cellular growth and triggering cell death. Lilach serves as a liaison mediating between the mathematical model analysis and the experiments performed in our partners' lab.

Publications

  1. Rosiglitazone induces caveolin-1 by PPARg dependent and PPRE-independent mechanisms: Role of EGF receptor signaling and effect on cancer cell drug resistance. L. Tencer, E. Burgermeister and M. Liscovitch. (2008) Anticancer Research, in press.
  2. Cloned myogenic cells can transdifferentiate in vivo into neurogenic cells. Rachel Sarig, Ora Fuchs, Lilach Tencer, Avi Panski, Uri Nudel and David Yaffe. (2007) Submmited.
  3. Caveolin-1 upregulates IGF-I receptor gene trascription in breast cancer cells via Sp-1- and p53-dependent pathways. G. Chen, L. Tencer, D. Ravid, R. Sarfstein, M. Liscovitch and H. Werner. (2006). Experimental Cell Research. 312 (19):3899-908.
  4. Caveolin and cancer: A complex relationship. M. Liscovitch, E. Burgermeister, N. Jain, D. Ravid, M. Shatz and L. Tencer. Membrane microdomain signaling: Lipid rafts in biology and medicine. (2005) M.P. Mattson, ed. (Totowa, New Jersey: Humana press), pp 161-190.
  5. Peroxisome proliferator-activated receptor-y upregulates Caveolin-1 and Caveolin-2 expression in human carcinoma cells. E. Burgermeister, L. Tencer and M. Liscovitch, (2003) Oncogene. 22: pp 3888-3900.
  6. Immunoglobulin light chains are dictate vesicular transport-dependent and -independent routes for IgM degradation by the ubiquitin-proteasome pathway. Y. Elkabetz, A. Kerem, L. Tencer, D. Winitz, R. R. Kopito and S. Bar-Nun. (2003) J. Biol. Chem. 278: pp 18922-18929.

Publications

  1. Oleg U. Kirnasovsky, Lilach Tencer, Genadye Vasserman, Zvia Agur. Dickkopf (Dkk) protein as a candidate for diverting proliferating cancer stem cells to terminal differentiation: Evaluation by a mathematical model. American Association for Cancer Research, AACR, Mar 16-19, 2008 Dead Sea, Jordan, pp 28.
  2. Burgermeister, E. and M. Liscovitchn (2006) -A role for EGFR, MEK1-ERK1/2 and p38 kinases in the induction of caveolin-1 by the PPAR ? ligand rosiglitazone and EGF. Proceedings of the 2nd joint American-Israeli conference on cancer (Jerusalem), p.90.
  3. Tencer, L, Burgermeister, E. and M. Liscovitchn (2006) A role for EGF receptor and MAP kinase signaling in the induction of caveolin-1 by the PPAR ? ligand rosiglitazone. Proceedings of ISREC 2006 (Lausanne), october 11-13.

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