Karin holds a Ph.D degree in Molecular Biology from the Weizmann Institute of Science Rehovot. Her Ph.D thesis was in the field of molecular and cellular biology and focused on the proto-oncogene c-Myc: as a transcription factor, inducer of apoptosis and the control of its degradation. She joined IMBM in January 2008. In IMBM she takes part in the Cancer Stem Cell project.
Work Program for 2008
- In the EU–FP6 NEST Project, [Contract no.012930] “Developing a virtual and molecular control board for diverting cancer stem cell to non-malignance “ project I am involved in the Neural Stem Cells model. I take part in developing a mathematical model describing the intracellular pathways responsible for the fate decision of neural stem cells and their role in cancer (with Yuri Kogan, Natalie Kronik and Zvia Agur).
- As part of the EU–FP6 NEST Project. I will be involved in developing a mathematical model of drug delivery to cancer stem cells (with Udi Hadad and Zvia Agur).
Publications
- Tobias K.E. & Kahana, C. (1993) Intersubunit location of the active site of mammalian ornithine decarboxylase as determined by hybridization of site-directed mutants. Biochemistry, 32, 5842-5847.
- Tobias, K.E., Mamroud-Kidron, E. & Kahana, C. (1993) Gly387 of murine ornithine decarboxylase is essential for the formation of stable homodimers Eur. J. Biochem. 218 , 245-250.
- Tobias, K.E., Shor, J. & Kahana, C. (1995) c-Myc and Max transregulate the mouse ornithine decarboxylase promoter through interaction with two downstream CACGTG motifs. Oncogene 11, 1721-1727.
- Tobias, K.E. & Kahana, C. (1995) -/posure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells. Cell Growth & Differ. 6 1279-1285.
- Gross-Mesilaty, S., Reinstein, E., Bercovich, B., Tobias, K.E., Schwartz , AL., Kahana, C. & Ciechanover, A. (1998) Basel and human papilloma virus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc. Natl . Acad. Sci. U S A, 95, 8058-8063.
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