Scientific activity in 2007

Mathematical modeling of monoclonal antibody treatment which includes: Mathematical modeling of monoclonal antibody treatment, analysis of a PK model for a specific monoclonal antibody drug (Mylotarg) for AML, validation of model predictions by experimental flow cytometry data obtained in a phase II clinical trial (with Vladimir Vainstein and Vincent van der Velden).

Work program for 2007

Developing individualized optimal treatment protocols using monoclonal antibody drugs in nonsolid tumors (with Vladimir Vainstein).

Publications

1. Jager E. and Segel L.A. On the distribution of dominance in populations of social organisms. SIAM J. APPL. MATH. 1992; Vol. 52, No 5: 1442-1468.
2. Segel L.A. and Jager E. Reverse engineering a model for T-cell vaccination. Bull. Math. Biol. 1994; 56: 687-722.
3. Segel L.A., Jager E., Elias D. and Cohen I. R. A quantitative model of auto-immune disease and T-cell vaccination: does more mean less? Immunology Today. 1995; 16: 80-84.
4. Segel L.A. and Jager E. T-cell vaccination via reverse engineering: transient disease. J. Biol. Syst. 1995; 3: 441-446.

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